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The recent evidence shows that the dUTPase protein encoded by EBV and HSV-1 can be transported to the brain via exosomes, where it induces pro-inflammatory cytokine release (e.g., IL-1, IL-6, TNF-) from endothelial cells, astrocytes, and pericytes, thereby degrading tight junction proteins, disrupting BBB integrity and inducing neuroinflammation [80]

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2014), resulting in an increased expression of 18-kDa translator protein, associated with the inflammatory activation of CNS (Chen and Guilarte 2008)

[DOI] [PubMed] [Google Scholar] 196.Heinz A., Schlagenhauf F

Many also give up food and sleep