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These cause chromatin condensation and transcriptional repression in adaptation to stress (Vincent et al., 2022)

However, Cys112 is in range to Met94, Phe136, and Val139, which are associated to a hydrophobic pocket, important in dimerization (Vargo et al., 2004)

However, it is widely recognized that aptamer enrichment is not always directly correlated with binding affinity due to factors such as PCR bias, selection pressure, and aptamer folding and structure 36

To ensure unbiased aptamer selection against CspZ via SELEX, the diversity of the initial oligonucleotides library was thoroughly validated and only a minor bias for guanines was observed (greater than 32%)