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Mutation of SHP2 accounts for more than half of the cases of Noonan syndrome, characterized by proportional short stature, facial dysmorphia, and heart disease (150)

Pyridoxines use in pregnancy, often in combination with doxylamine, has not been associated with teratogenic effects in either the first trimester or later trimesters

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Overall, oncologists exhibited moderate alignment with evidence, demonstrating a tendency to permit rather than actively recommend complementary therapies, even when evidence indicated potential benefits and safety