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Recent work using Saccharomyces cerevisiae and LPS-primed bone marrow-derived macrophages show mitochondrial electron transport chain-derived ATP induces NLRP3 inflammasome activation through phosphocreatineATP-dependent mechanisms independent of mitochondrial ROS 49

2931 Short-term flupirtine, 100 mg twice daily, treatment in patients undergoing lower limb surgery and gynaecological ambulatory surgeries reduced pain levels comparable with, and gave patient satisfaction scores similar or superior to, the non-steroidal anti-inflammatory drugs (NSAID) piroxicam and ibuprofen

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