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To deepen our understanding of the impaired lysosomal function, we next evaluated the presence of the early and late lysosomal damage markers GAL3 and K48 and the repair marker CHM4b 53

Each pathway is regulated by various factors (eg, stem cell factor, thrombopoietin, various interleukins, erythropoietin, etc), and key specific transcription factors (not indicated in the figure) are also involved at the stages indicated