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These strategies utilize the extended circulation duration of RBCs and their immune clearance, while enabling the expression of therapeutic proteins or enzymes, potentially addressing metabolic disorders or compensating for deficient enzymes (85)

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To construct cDNA libraries, SMARTer smRNA-Seq Kit for Illumina kit ((Illumina, San Diego, CA) and TruSeq SBS Kit v3 (Illumina)were used

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Studies have examined their effects on wound healing in diabetic patients, collagen synthesis in human skin, hair follicle enlargement and gene expression in skin cells