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Drugs administered by IN penetrate through the nasal epithelial barrier, followed by diffusion into the perivascular or perineural spaces, and finally throughout the brain though some of the drug will be lost by entering the lymphatic and systemic blood circulation [12]

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Gramer, Gwendolyn et al

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Based on the geroscience concept that aging and age-related disease conditions are associated with the same pathways [2,3], resilience to aging, as measured by ability to recover from physical stress, provides a resistance environment for preventing or delaying the onset of age-related conditions

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