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In the prefrontal cortex and cerebellum, significant reductions in GABAA receptor density further indicate that GABAergic function is suppressed in these regions ( Additionally, reduced activity of PV expressing neurons in the V1 region of Fmr1 knockout mice may be associated with deficits in perceptual learning

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141,142 Recurrent somatic mutation of residues are mainly located at enzymatic active sites that bind to isocitrate, typically at R132 including R132H, R132L, R132S, R132C, and R132G in IDH1, and R140Q or R172K in IDH2

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