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However, melatonins receptors can be Gq-coupled and activate phospholipase C (PLC), which hydrolyzes phosphatidylinositol 4,5-bisphosphate (PIP2), producing inositol triphosphate (IP3) and 1,2-diacylglycerol (DAG), which increases Ca +2 levels and activates calmodulin (CaM) and CaM kinase signaling [158, 159]

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Notably, statins inhibit YAP/TAZ activity, thereby reducing disturbed flow-induced proliferation and inflammation (126)

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