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Chapter 58: The Great Vessels, In: Grays Anatomy 42 nd British edition

POLG-related disorders should be suspected in patients with a family history or suggestive symptoms of a POLG-related disorder, including but not limited to unexplained encephalopathy, refractory epilepsy (focal, myoclonic), status epilepticus at presentation, developmental delays, psychomotor regression, axonal sensorimotor neuropathy, myopathy cerebellar ataxia, ophthalmoplegia, or complicated migraine with occipital aura

Outside of confirmed deficiency states, the use of L-carnitine supplements is largely driven by the sports nutrition and weight management market rather than by formal clinical guidance from NICE or the NHS

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If combining with medications, discuss with a healthcare provider first