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Although all the organ systems age progressively with time, the female reproductive system stands out

More recently, pure ergotamine has been used for the treatment of migraine headaches

In the cardiovascular system, senescent cells in the blood vessels promote arterial stiffness and endothelial dysfunction, increasing the risk of hypertension and atherosclerosis.25 In the brain, the buildup of senescent cells has been implicated in neurodegenerative diseases such as Alzheimers and Parkinsons, where they exacerbate neuroinflammation and neuronal loss.26 Similarly, in adipose tissue, the accumulation of senescent cells contributes to insulin resistance and the development of metabolic disorders such as type 2 diabetes.27 Senescent chondrocytes promote cartilage degradation and joint inflammation

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But does it work, or is it just another overhyped trend