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doi: 10.1038/cdd.2017.170 43 ZhengJAsakawaTChenYZhengZChenBLinMet al

The function of mitochondria also plays a vital role in cell health, intercellular communication, regulated cell death, and cell growth

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The pathogenetic mechanisms of macrovascular complications include the production of advanced glycation endproducts (AGEs), NO decrease, increased oxidative stress, lipid peroxidation and platelet dysfunction
489 Both MT overexpression and direct MT administration can reduce DCM by suppressing peroxynitrite-derived nitrosative damage and ROS production in diabetic hearts
