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Since 2017, the National Institute for Health and Care Excellence (NICE) has recommended that all people with colorectal cancer are tested for Lynch syndrome using Immunohistochemistry (IHC) or Microsatellite Instability (MSI) testing (DG27)

Botelho, I.M.B., Moura, N.A., Silva, C.A., Tambascia, M.A., Alegre, S.M., Zantut-Wittmann, D.E
Patients should be informed about the signs of serious skin reactions, and use of the drug should be discontinued at the first appearance of skin rash or any other sign of hypersensitivity

This reaction involves an enzyme that removes the adenosine group

Neural Circuits 6 , 47 (2012)
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