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Therapeutic strategies aimed at suppressing inflammation, such as corticosteroids, are being explored to mitigate drug-induced ototoxicity (Fang et al

Metabolically, we observed an up-regulation of glycolysis and lactate production with a concomitant reduction in carbon from glucose entering the pentose-phosphate pathway and the TCA cycle

Primer extension studies show that in liver, kidney, lung and placenta, the major transcription start sites are located 250 and 249 bp upstream of the translation start site and 100 bp upstream of the second major site, encoding a protein with 509 amino acids [16]

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