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Description
When your mucosal barrier is compromised, those tight junctions between cells in the intestinal walls open up, leading to small gaps where bacteria and other toxins can move freely
Sohal RS, Farmer KJ, Allen RG, Ragland SS, 1984
In support of this, SELENON knockout mice have lower blood glucose and faster muscle and liver glycogen depletion in response to exercise (43) potentially indicating an increased reliance on anaerobic glycolytic metabolism
Org Biomol Chem 6:2731
While the analogy isn't perfect, it captures the essence of why researchers often prefer localized protocols for joint-specific studies
