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Based on the positive effects reported in previous studies, further testing is warranted in various populations that may benefit from nutritional supplements, including aerobic and anaerobic athletes, resistance-trained individuals, elderly people, and clinical populations, to determine the impact of different doses, timing of ingestion, and long-term and acute effects of Arg, Cit, and CitMal supplements on cardiovascular health and athletic performance

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Summary: Amino acids, particularly L-arginine and L-citrulline, may provide modest benefits for mild to moderate erectile dysfunction, but evidence is mixed and they are not recommended as first-line treatment in UK guidance

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Injections are performed once every two weeks over a three month period and may be repeated if the need for more improvement exists