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In contrast, ethanol-mediated inhibition of SIRT1 disrupts the lipid-1 pathway, leading to steatosis through an altered lipid-1/ ratio (Yin et al., 2014)

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MASLD is bidirectionally associated with metabolic disorders related to IR, such as T2DM, polycystic ovary syndrome (PCOS), obesity, and dyslipidemia [65, 66]

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