melanotic macules. macule. Benign. Dark spot on labia (or lip). Analogous to lentigo simplex. Hyperpigmented basal keratinocytes & dermal melanophages. Slight ⬆️ in single basal melanocytes; NO nests. More info like this in Labial melanotic macule (brown spot
Description
In chicken embryos, mice and rats, a heat-shock induced HSP, Hsp47 has been found to specifically bind procollagens in the endoplasmatic reticulum and participate in collagen biogenesis [97]

New York: Garland Science (2002)
But Columbus still persevered in his determination to reach Asia by a western route

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