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Hence, the hub-bottlenecks (HB) nodes are the most topologically relevant nodes and retain critical regulatory roles within the cell, being classified as bridges between biological processes and key molecular modulators (Yu et al

Briand, O

10.3748/wjg.v23.i4.668 World J

[DOI] [PubMed] [Google Scholar] 23.Zhang Z, Gupte MJ, Jin X, Ma PX

Thus, delivering a combination treatment in one entity as a prodrug may be successful in using either mechanistic pathway of cell death and avoiding development of resistance [166,167]
