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The decrease in NAA may be a consequence of mitochondrial dysfunction and abnormal energy metabolism (36)

doi: 10.1016/j.cgh.2011.12.039

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Under energy stress conditions, AMPK directly phosphorylates the autophagy-initiating factor ULK1 at serine residues 317 and 777, promoting autophagosome formation ( 4.5 The interaction network of AMPK with other metabolic pathways The functional roles of AMPK extend beyond its classical functions to dynamic interactions with other metabolic pathways