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Scanning electron microscopy analysis reveals that hairs from GHK-Cu-treated models show more regular cuticle structure, increased cortical density, and improved overall fiber integrity

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This study not only elucidates the mechanisms of PARP1-mediated PXR E194 ribosylation in AILI but also identifies Sch B as the first specific inhibitor of this pathway, providing a theoretical basis for precision detoxification strategies targeting posttranslational modifications.

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