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Too much caffeine may cause high blood pressure, rapid heartbeat, nausea, vomiting, nervousness and trouble sleeping

Reactive species such as O 2 , OH , RCOO and ONOO are all potent initiators of lipid peroxidation

Further studies are needed to clarify the relative antioxidant power and role in microbiota maintenance of glutathione, ascorbic acid, uric acid, proteins, including glutathione-associated enzymes (glutathione-S-transferase (GST) and glutathione peroxidase (GPX)), alpha-tocopherol 38 , beta-carotene 38 and gut bilirubin derivatives (urobilin, stercobilin and protoporphyrin) 39 in the gut