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While comorbid conditions like long COVID, fibromyalgia (FM), and postural orthostatic tachycardia syndrome (POTS) are common in ME/CFS, the more critical diagnostic complication arises from symptom presentations that resemble pre-malignant states, and undiagnosed rheumatic diseases, neurological diseases and endocrinopathies, increasing the risk of misdiagnosis

doi: 10.1016/j.mimet.2018.11.007 52 KumarRHeroldJLSchadyDDavisJKopetzSMartinez-MoczygembaMet al