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While other mouse models with mitochondrial disturbances shift to using glucose as a fuel source, NFS1 KD results in insulin insufficiency and glucose intolerance
Besides, combining phenotypic and target-based approaches becomes a third strategy to be considered for T

Conversely, H 2 S also constitutes a signaling molecule, as revealed by a landmark paper showing its neuromodulatory effects 97

So far, many upstream signals have been implicated in both mitochondrial biogenesis and mitophagy as described above
