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Change history 16 November 2011 This paper was modified 12 months after initial publication to switch to Creative Commons licence terms, as noted at publication References Adams TE, Epa VC, Garrett TP, Ward CW (2000) Structure and function of the type 1 insulin-like growth factor receptor

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Key risk factors for developing NAFLD include: Obesity , particularly central adiposity (excess abdominal fat) Type 2 diabetes mellitus and insulin resistance Dyslipidaemia (abnormal cholesterol and triglyceride levels) Metabolic syndrome (a cluster of conditions including hypertension, hyperglycaemia, and abnormal lipids) Sedentary lifestyle and poor dietary habits The underlying pathophysiology involves insulin resistance, which leads to increased delivery of free fatty acids to the liver, enhanced hepatic fat synthesis, and impaired fat oxidation

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The results of competitive counter-flow experiments indicated that T4 and T3 (but not rT3 or T4-gluconuride) were indeed substrates for OATP2B1