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The observations during the baseball game travel suggested that the hypobaric/hypoxic stress induced by road travel through Eisenhower Tunnel (0.66 ATA) on the patient's dementia ( Treatment The patient was initiated on daily 1.6 g sublingual glutathione amino acid precursors 3 weeks prior to hyperbaric treatment

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Therefore, decreased mPFC taurine levels might limit the defensive capabilities of mPFC neurons and NAC could potentially compensate for this loss by enhancing GSH synthesis and rebalancing the local redox system

Since 2020, 8 of the 20 published clinical trials have focused on neurodevelopmental and neuropsychiatric/cognitive disorders, exhibiting a significant rise in clinical trials exploring sulforaphanes efficacy in the CNS compared to the previous two decades where only two of 57 trials focused on ASD alone with no published trials examining other CNS disorders (Supplementary Table 1)