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3840 When free radicals attack intestinal epithelial cells (IECs) and cause damage, the death of IECs increases, the expression of intestinal tight junction proteins decreases, and the permeability of the epithelial barrier increases, which lead to the invasion of intestinal bacteria and other antigens into the intestinal mucosa

subsequently, celastrol (Cel) was added to prepare Cel-loaded diblock copolymer nanomicelles (C-PEPS)

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Epileptogenesis arises from excessive excitability in hyper-excitable neurons and glial cells, which synchronize and spread to previously normal, non-epileptogenic tissue