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Inhibiting FMO3 expression in the liver or decreasing FMO3 activity with drugs is another technique for lowering plasma TMAO levels and delaying the progression of AS

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Table 1 shows the detailed inclusion, exclusion, and removal criteria

HMGCR catalyzes the conversion of HMG-CoA to mevalonate in the first phase, while squalene is oxidized by SM in the third stage to produce 2,3-oxidized squalene, a precursor of cholesterol and sterols

Concentric left ventricular hypertrophy is the most common structural myocardial abnormality in HFpEF, typically resulting from cardiomyocyte hypertrophy and myocardial interstitial fiber deposition