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In a breast cancer xenograft model (MDA-MB-231), mitochondria-targeted nanomedicines co-assembled from berberine and doxorubicin effectively repairs mitochondrial protein defects (Mfn1/Drp1) and inhibits the activity of MMP-2 and MMP-9, resulting in significant suppression of tumor cell proliferation and lung metastasis [242]

De Stefani E, Ronco A, Mendilaharsu M, Guidobono M, Deneo-Pellegrini H: Meat intake, heterocyclic amines, and risk of breast cancer: a case-control study in Uruguay

Another study indicated that Tingli Dazao Xiefei Decoction has the potential to ameliorate NO-CO metabolic disorders in both lung tissue and intestine simultaneously

Like the ACHI and modified weight drop models, the lateral impact model aimed to replicate clinically relevant biomechanics and pathophysiology of mTBI [154, 174]

Schartz D, Li M, Vaccaro A.R., Hilibrand AS, Mirarchi N, Matsumoto C, Sestokas A, Strantzas S, Albert TJ
