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3A expansion of the 1H-NMR spectrum of SAG form B in the 1.8-5 ppm range FIG

Although paraquat may not be an efficient inhibitor of mitochondrial complex I, and so does not affect dopamine uptake [87,88], it does cause -synuclein aggregation in C57Bl/6 mice, and alters Parkin solubility, decreasing proteasome activity and causing cellular damage [87]

[17] [18] From all this it follows that the kinetic/catalytic properties of the different isozymes depend on the prevalence of one of the two subunits

As in most metabolic pathways, the first reaction that is unique, known as the committed step , is essentially irreversible