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This also applies to wash in - it will take ~4-5 elimination half-lives of a drug for a constant-rate infusion to reach its final concentration Half-life is mathematically related to many other key pharmacokinetic terms: Various types of half-life are described: t 1/2 describes the rapidity of the distribution phase following drug administration t 1/2 describes the rapidity of the elimination phase occurring after drug distribution equilibrium This only evaluates clearance from plasma, and so is a composite of both excretion from the body (e.g

Lee H, Shi W, Tontonoz P, Wang S, Subbanagounder G, Hedrick CC, Hama S, Borromeo C, Evans RM, Berliner JA, Nagy L

With a precise dosage, the NASA spray formulation has been shown to work faster and more reliably than the oral form to treat motion sickness

[DOI] [PubMed] [Google Scholar] 128.Moncada S, Palmer RM, Higgs EA

J., Butler W