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Discussion We have previously reported that IGF-1 can activate PI3K/AKT pathway in the rat retina and that expression of IGF-1 and p-IGF-1R declines during postnatal retinal development (Maturana-Teixeira et al., 2015) in parallel with a remarkable decrease in retinal cell proliferation (Braga et al., 2013)

Ddx3x fl/y mice (two out of 12), underscoring a remarkable survival advantage compare to their littermates (Fig

Parallel induction of heme oxygenase-1 and chemoprotective phase 2 enzymes by electrophiles and antioxidants: regulation by upstream antioxidant-responsive elements (ARE)

Therefore, collectively, these findings suggest that administering NAD + precursors prevents oxidative stress and mitochondrial dysfunction, and hence may be a useful therapeutic target for ALS

Ion dynamics are quantified and predicted by the Nernst and the Goldman equations , elucidating the equilibrium potential and the membrane potential , respectively