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For example, homologues with CxxS- and CxxC-motifs at the active site are classified as monothiol and dithiol glutaredoxins, respectively

This concentration gradient makes transport of GSH from outside the cell to inside the cell thermodynamically unfavourable

107,109 Furthermore, it is questionable whether ferrostatin-1 can eliminate injury in the presence of significant damage but limited LPO

doi: 10.1016/j.abb.2005.06.010

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