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The liver is a key target organ for methylation reactions where SAM is the methyl donor (Figure 1(a)) and participates in posttranslational protein modifications, DNA and histone tail methylation, as well as many metabolic pathways such as creatine synthesis [1315], carnitine synthesis [16, 17], and endogenous phosphocholine synthesis [18]

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10.1016/j.drugalcdep.2012.12.005 27 CherpitelC

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doi: 10.1186/1742-2094-11-81