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Similarly, topiramate decreased its MDA levels and increased GSH levels in a study on the prevention of flap necrosis after plastic and reconstructive surgery ( However, in a study on the potential toxic effects of topiramate on the liver and kidney of male mice, topiramate significantly decreased the activities of the antioxidant enzymes SOD and CAT, while increasing MDA and NO levels ( In vitro study found that topiramate increased MDA, NO and ROS production in astrocytes, showing a dose-dependent negative effect (Pavone and Cardile, 2003)

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In chronic VPA use, it is probably a more reliable indicator of total body stores

[DOI] [Google Scholar] 94.Teichert J., Tuemmers T., Achenbach H., Preiss C., Hermann R., Ruus P., Preiss R