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Abstract Mast cells are involved in immune disorders so that many of the proinflammatory and tissue destructive mediators produced by these cells have been implicated in the pathogenesis of rheumatoid arthritis

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Homocysteine is currently one of the most likely candidates

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Elevated NO levels can cause S-nitrosylation of key proteins such as protein disulfide isomerase (PDI), which disrupts folding homeostasis and contributes to neurodegenerative conditions including PD and AD

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Faecalibacterium maintains intestinal epithelial energy homeostasis and exerts anti-inflammatory and barrier-protective effects via the butyratePPAR axis (50)

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