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Chirality 2021;33(10):597-601
doi: 10.1016/j.bbrc.2011.09.006 103 ZhouJLiQLiuCPangRYinY
The Role of Epigenetic Modifications in Human Cancers and the Use of Natural Compounds as Epidrugs: Mechanistic Pathways and Pharmacodynamic Actions
Notably, pulmonary tissues lack essential substrates for SCFA biosynthesis (e.g., dietary fiber), and germ-free mouse models exhibit significantly reduced pulmonary SCFA levels - direct evidence that lung SCFAs are entirely dependent on functional gut microbiota-derived interorgan supply (Liu Q
This highlights the need for careful interpretation of the observed associations
