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3.1.2 -amyloid (A) and tau proteins A accumulation in multiple brain regions and hyperphosphorylation of tau proteins are also pathological alterations in PD, resulting in neuroprogenitor fibril tangles (Wills et al., 2010)

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and R 4 and R 5 taken together form a fused 4-membered ring that is optionally substituted with Me or OMe 52