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124 Additionally, both CBS and CSE can catalyze -substitution reactions, resulting in the condensation of two L-Cys molecules to produce H 2 S and lanthionine, or the condensation of L-Hcy and L-Cys through , -substitution reactions to produce H 2 S and cystathionine

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In other words, the cell danger response turns on as it should, but cannot turn off when the danger is no longer there

There is at least partial and temporary relief by activity such as walking [1]