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Description
Unlocking opioid neuropeptide dynamics with genetically encoded biosensors

Results : Twenty patients with a mean age of 63.1 16.6 SD were enrolled

In BV2 microglial cells, BV2-metformin-loaded PLGA treatment downregulated inducible nitric oxide synthase (iNOS) expression (proinflammatory M1 phenotype) and upregulated mannose receptor (CD206) expression (anti-inflammatory M2 phenotype), leading to a more than three-fold elevation in the CD206/iNOS fluorescence intensity ratio

& Meng, W

It plays a crucial role in regulating and boosting the immune system's response to pathogens, infections, and diseases
