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The degradation rate also depends on the number of bacteria introduced when piercing the vial, which is unavoidable to some extent

EClinicalMedicine 11, 1117

PMID 7811344
Lipid peroxidation not only directly damages cell membrane phospholipid structure and neuronal function but also decomposes into highly reactive electrophilic aldehydes including 4-hydroxynonenal (4-HNE) and malondialdehyde (MDA) (82, 83)

Cancer Genome Atlas Network
