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529 In a phase I/IIa, single-arm study on human umbilical cord-derived MSCs (UMSCs), 47.1% of the 17 patients with psoriasis had at least 40% improvement in the PASI score during the treatment with UMSC infusion and through 6 months of follow-up, with a significant increase in Tregs and CD4 + memory T cells and a significant decrease in Th17 and CD4+ naive T cells in the peripheral blood after UMSC transplantation