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Arch Biochem Biophys 726:109231

Vitamin B6 & B12 contributes to normal homocysteine metabolism

Increasing the capacity of the TCA cycle improves the energetic status of the cell and in order for neurons to benefit from anaplerosis, glutamine derived from TCA cycle intermediates are transferred from astrocytes to neurons where they are re-converted to intermediates, thereby increasing the capacity of the TCA cycle to produce energy [19]