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Selecting neutral or zwitterionic lipids, controlling the encapsulation temperature (often below the protein's denaturation point), and adding stabilizing excipients such as trehalose or sucrose can significantly enhance protein preservation

However, the critical limitation remains the near-total absence of rigorous human clinical trial data

Intestinal short chain fatty acids and their link with diet and human health

Adjusting the dose and frequency is key in the maintenance phase

The approach demonstrates how peptides can be designed to target specific aspects of lupus autoimmunity rather than the immune system as a whole