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Exclusion criteria The presence of serious somatic disorders, substance abuse except for cigarettes and caffeine, and history of high mood (mania or hypomania), mental dysfunction, dementia, acute psychiatric disorders according to the psychiatrist, and medication that causes depression in the patient were excluded from the study

doi: 10.1038/srep26933

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These ratios are modulated by NAD + precursor availability and are significantly altered under pathophysiological conditions

Baba Y, Kuroiwa A, Uitti RJ, Wszolek ZK, Yamada T