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While the C-terminal unit (C0362) is secreted and functions as a cysteine protease that disarms the complement system via degrading key complement factors such as C3 and C4, the N-terminal functional unit (N0362) with two Big domains binds to FPR1 and CXCR1/2 receptors with high affinity and blocks neutrophil chemotaxis and activation most likely through competition inhibition, thereby annihilating both the complement system and neutrophils and rendering bacteria protection from these two innate defense mechanisms

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Together, their collective genetic material forms the microbiome, and they inhabit various body regions in staggering numbers (Schirmer et al., 2018)

2.3 Animal models and ethical approval All animal experiments were conducted in accordance with the guidelines of the Animal Ethics Committee of Guilin Medical University (Ethics Approval No

Thus, it is further important to do further studies on new molecular markers and non-invasive diagnostic tests for an improved accurate diagnosis of thyroid cancer (Jaiswal and Gurudiwan 2023)