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Further experiments confirmed that miR-499-5p targets SOX6 , a specific factor known to inhibit the expression of slow-twitch muscle genes, and miR-196-5p targets CALM1 , a key element in the cGMP-PKG and calcium signaling pathways

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[163]) might be related to osmotic stress rather than pathological modification of the eye lens and that chronic aberration of osmotic pressure causes net loss of carnitine which can lead to triggering of cataracts