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This misconception stemmed from early studies suggesting that AAV2 vectors induce minimal and temporary innate immune activation, unlike the strong and prolonged adaptive responses triggered by Ad vectors [113]

Laboratory tests showed severe pancytopenia, with the following results: hemoglobin (Hb): 3.3 grams per deciliter (g/dl), white blood cell (WBC) count: 1.72 10 9 /L, platelet count: 28 10 9 /L, mean corpuscular volume (MCV): 100 femtoliters (fL), and absolute neutrophil count (ANC): 1.07 per microliter of blood (muL)

Cuprizone-brain damage and motoric disability The used cuprizone regimen, several times higher than those regularly used in cuprizone studies (62), rapidly induced marked functional disability along with severely affected various brain areas