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Moreover, the liver metabolizes common organochlorines encountered in occupational exposures, such as PCE and TCE
J Med Chem (2012) 55(16):7193207

The De Novo Pathway begins with the condensation of L-serine and a fatty-acyl CoA such as palmitoyl-CoA, myristoyl CoA, or stearoyl CoA at the endoplasmic reticulum catalyzed by the enzyme serine palmitoyltransferase (SPT) to form 3-ketosphinganine, which is then reduced to dihydrosphingosine by the NADH-dependent 3-ketosphinganine reductase (KDSR)

doi: 10.1161/01.RES.86.2.125 [DOI] [PubMed] [Google Scholar] 49

4 Skin Thickness and Hydration A pilot study on topical copper tripeptide complexes confirmed increases in both epidermal and dermal thickness, improved hydration, visible smoothing from stimulated collagen synthesis, and increased skin elasticity
