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Although normal electron transport in mitochondria involves four-electron reduction of molecular oxygen to water, partial reduction reactions occur even under physiologic conditions, causing release of O 2 and hydrogen peroxide

This study suggested that HIF-1 signaling in NK cells is a key node for coordinating skin antibacterial defenses and tissue repair

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Ferroptosis, induced by lipid peroxidation, is dependent on metabolites ROS, phospholipids containing polyunsaturated fatty acid chains (PUFA-PL), and the transition metal iron